Tottenham will be spending the whole season at the national stadium as work continues on their new £850m ground – and you couldn’t have asked for a much tougher game to get you started.
The Blues come in to this match on the back of a humbling 3-2 defeat on the opening weekend against Burnley, and will be looking to set that record straight.
Spurs won last week – but who are the experts predicting to win on Sunday? And what do the bookies think?
This is Tottenham’s first Premier League game at Wembley but it will not be quite the test that people were expecting when the fixtures came out.
I just think Chelsea are all over the place, as we saw against Burnley last week.
They are without suspended duo Gary Cahill and Cesc Fabregas after their red cards against the Clarets and Eden Hazard is not ready to return from injury yet.
Pedro and Tiemoue Bakayoko are also injured and there is no end in sight to the Diego Costa saga either, with the striker still in Brazil. The situation with him is just absurd.
So I am going to go for a Spurs win – if I am right, then Chelsea really are in crisis, aren’t they?
Chelsea won’t lose here. I think both teams will be more than happy with a draw. You have to remember that the last thing Tottenham want to do is lose this game – their first at Wembley this season – and Chelsea can’t afford to lose a second game on the bounce.
Both teams will be nervous and I think it will be quite cagey.
If not a draw I would probably go Chelsea. I was not impressed with Tottenham at Newcastle, I thought they were poor.
The first-ever Premier League game played at Wembley Stadium and it will be impossible for Spurs to improve on their remarkable unbeaten home record last season at White Hart Lane.
Indeed, Spurs have won 14 home Premier League games on the spin and will break their club record if they can beat the Champions on Sunday.
Antonio Conte will have to do without both Gary Cahill and Cesc Fabregas through suspension and, make no mistake, this is a huge game for both clubs even at this early stage of the season.
Spurs have only won one of their last nine games at Wembley – but I expect them to double that tally with Harry Kane taken to score his 100 goal for Spurs.
Prediction: Spurs win
Spurs go in to this match as big favourites with Skybet at 11/10, with Chelsea back at 13/5 and a draw priced at 5/2.
If you fancy a bet on the first goalscorer – then Harry Kane is your 7/2 favourite, with Dele Alli just behind him at 5/1.
The best priced Chelsea players to net first are Alvaro Morata and Michy Batshuayi – who have priced of 6/1 and 13/2 respectively.
However, if you want to place a bet on something a bit different…
After two reds cards in Chelsea’s match last week and one in Tottenham’s – you can get a price of 9/4 for a player to be dismissed on Sunday.