Jose Mourinho’s side will take to the field for the first time since losing Paul Pogba to a hamstring injury but the Portuguese boss was adament this week that he had the squad to cope.
Marouane Fellaini will be the man to step into midfield while left-back Luke Shaw is also available but has failed to make the match-day squad.
Dominic Calvert-Lewin could partner Rooney in the Everton attack as Ronald Koeman looks for a response from his team after two abject defeats – against Tottenham and Atalanta.
Take a look at the confirmed teams below:
Manchester United XI: De Gea, Valencia, Bailly, Jones, Young, Fellaini, Matic, Mata, Mkhitaryan, Rashford, Lukaku
Substitutes: Martial, Smalling, Lingard, Carrick, Romero, Ander Herrera, Darmian.
Everton XI: Pickford, Keane, Jagielka, Williams, Martina, Schneiderlin, Gueye, Baines, Davies, Sigurdsson, Rooney
Substitutes: Sandro, Mirallas, Klaassen, Besic, Stekelenburg, Calvert-Lewin, Holgate