The Swiss U21 star, who held down a regular spot in pre-season, has seen off competition from Declan Rice to start in centre midfield at Old Trafford as Cheikhou Kouyate is ruled out through injury for the at least the first three games of the season.
With Toni Martinez’s inlcusion for the Hammers U23s on Friday night against Everton – he was a candidate to start at United – so now it surely falls on Hernandez to spearhead the attack, despite Slaven Bilic saying on Friday the Mexican was not 100 per cent fit.
Club-record signing Marko Arnautovic and his new number 27 shirt is included from the start on the left wing, while Arthur Masuaku starts at left back as Aaron Cresswell has failed to recover from injury. The same fate befalls Manuel Lanzini, who will miss at least the first two games of the season.
Arnautovic is supported by Andre Ayew on the right hand side of a front three that includes Hernandez.
Winston Reid, despite his red card and lack of match practice throughout pre-season, should get the nod alongside Angelo Ogbonna at the heart of the defence, with Jose Fonte reduced to a spot on the bench.